Archive: Company News
Company News: Humabs BioMed Reports Clinical Milestone in MedImmune Partnership
– MedImmune Starts Phase I Clinical Trial to Investigate an Antibody Developed Under a Collaboration with Humabs for the Treatment of Influenza A –
Humabs BioMed SA, a leading Swiss antibody therapeutics company, today announced that a novel antibody developed through its proprietary Cellclone technology will be investigated for the treatment of influenza A in a Phase I trial being conducted by MedImmune, the global biologics research and development arm of AstraZeneca.
The investigational antibody, which has broad influenza-neutralizing properties, was isolated by Humabs from human memory B cells and further optimized for higher potency by MedImmune. The resulting antibody, MEDI8852, is exclusively licensed to MedImmune. The Phase I trial (NCT02350751) is designed to evaluate the safety and pharmacokinetics of MEDI8852 in healthy adults.
MEDI8852 binds to a novel site in the hemagglutinin stem region that is shared in viruses from all 18 Influenza A subtypes. This region is highly conserved and is considered to be the “Achilles’ heel” of the virus.
Humabs discovers and develops antibodies directly derived from individuals whose immune systems have successfully responded to major diseases. While the concept of isolating antibodies directly from recovered patients is not new, Humabs has developed a unique, comprehensive scheme for screening and selecting naturally occurring antibodies. Its proprietary technology platforms use immortalized donor B cells or cultured plasma cells with unmatched, stable secretion rates. This allows Humabs to perform sophisticated functional screens to rapidly discover antibodies able to opsonize or kill bacteria, block viral entry, or eliminate virus-infected and cancer cells. Instead of looking for binders to predefined targets, the Humabs functional approach is target-agnostic. Within weeks, it leads to ultra-potent antibodies, which can subsequently be developed for therapeutic, diagnostic, or research purposes, including the identification of novel targets or vaccines.
Company News: Merus reaches pivotal milestone in bispecific antibody collaboration with ONO PHARMACEUTICAL CO., LTD.
– Successful product lead identification underscores the strength of Merus’ platform in delivering human, full-length IgG bispecific antibodies –
Merus B.V., a leader in developing best-in-class bispecific antibody therapeutics, announced today that it has reached a preclinical milestone in a bispecific antibody research and license collaboration with ONO PHARMACEUTICAL CO., LTD. (Osaka, Japan, ”ONO”) triggering a payment. The milestone is for achieving preclinical proof-of-mechanism with a lead bispecific antibody directed against a target combination relevant in the treatment of autoimmune disease.
Company News: Anergis Announces Completion of Treatment in AllerT Phase II Dose-Ranging Trial
– 213 patients included in trial of novel ultra-fast allergy immunotherapeutic
Anergis, a company developing novel and proprietary ultra-fast allergy immunotherapeutics, today announced treatment completion of its Phase II clinical trial of AllerT, a novel long-peptide immunotherapeutic to treat birch pollen allergies. In the trial, 213 patients were randomized to receive target doses of 10, 25 or 50 µg of AllerT or placebo as 5 subcutaneous injections over 2 months. The last patient was treated at the end of March. No serious adverse events and no grade 3 or 4 allergic reactions were reported. The trial is being conducted in Canada and is still blinded. Results are expected in Q3 of 2015.
Company News: ISA Pharmaceuticals Granted European Patent for the Intradermal Administration of ISA101
– Intradermal administration provides significant benefits compared to subcutaneous application
ISA Pharmaceuticals B.V., a clinical-stage immunotherapy company focusing on rationally designed immunotherapeutics against cancer and persistent viral infections, today announced it has been granted a European patent (patent no. EP 2 155 240) for the intradermal administration of synthetic long peptides (SLP®s) based on HPV oncogenes, including its lead compound ISA101.
Specifically, the patent was granted for the therapeutic use of intradermally delivered long peptides derived from the E2, E6 and/or E7 proteins of the human papillomavirus (HPV) to treat or prevent HPV-related diseases.
ISA101 is a clinical-stage immunotherapeutic for the treatment of early-stage, advanced and recurrent cancers induced by HPV16 infections and is based on ISA Pharmaceuticals´ proprietary SLP® platform. The compound is currently in clinical Phase I/II trials in cervical cancer and anal intraepithelial neoplasia (AIN).
As shown in healthy volunteers, intradermal administration of low doses of the HPV16 E6 and E7 SLP® without any adjuvant resulted in an effective, long-lasting systemic T cell response. This shows that, compared to subcutaneous delivery, the new epidermal routing with lower doses and absence of a concomitant adjuvant is also capable of eliciting a robust immune response in naïve individuals.