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Company News: Molecular Health Opens Berlin Office to Support Growing Demand for Digital Health Solutions

– Company strengthens relationships with policy makers and patient advocacy groups –

Molecular Health, a leader in cloud-based healthcare decision support technology to enable evidence-based treatment decisions and improved outcomes, today announced that the company has opened an office in Berlin, Germany to accelerate the growing European demand for its suite of digital health solutions.

Located on Friedrichstrasse in downtown Berlin close to the government district, the new office reflects Molecular Health´s continued corporate growth and will enable the company to further strengthen its relationships with policy makers and patient advocacy groups in Germany.

Renowned guests at the opening event on November 12, 2015 included Prof. Dr. Christiane Woopen, Chairman of the German Ethics Council and an expert in genome analysis, and Dr. Friedrich von Bohlen, Founder and Chairman of the Board of Molecular Health.

Company News: NEO New Oncology AG begins clinical study on molecular diagnostics for lung cancer patients

NEO New Oncology AG announced today the launch of its prospective registry “NEOlung”. In this study, approximately 1,500 patients with advanced or metastatic lung cancer will gain direct and timely access to comprehensive molecular diagnostics and close-to-home care in specialized centers in Northern Germany.

With NEOlung, NEO New Oncology AG will employ its NEO technology to offer comprehensive tumor analysis in addition to standard histopathological diagnosis for each participating patient. NEO is able to provide rapid and comprehensive analysis of all therapeutically-relevant genetic alterations from either a blood sample or a minimal quantity of tissue. In addition to point mutations, both translocations and copy number changes, all of which play an increasingly important role in the treatment of lung cancer, are detected. The aim of NEOlung is to establish a prospective, non-interventional registry in order to evaluate the quality and performance of the NEO technology in its ability to detect therapeutically relevant genomic alterations. Furthermore, the efficacy of treatment using targeted substances in different lines of therapy, the progression of tumor diseases and the emergence of resistances in clinical practice will be recorded prospectively. Data pertaining to health economics will also be collected and evaluated. Finally, NEO will be compared to standard molecular diagnostics methods as well. NEOlung is financed by NEO New Oncology AG.

NEOlung will be performed at centers of the NOWEL network, which aims to ensure optimal, region-wide accessible care for lung cancer patients across all of Northern Germany.

Company News: NOWEL network established for the optimal care of lung cancer patients in Northern Germany

The Pius Hospital Oldenburg, the Institute of Haematopathology Hamburg and NEO New Oncology AG announced today the formation of NOWEL, the North-East-West Lung Network (Nord-Ost-West-Lunge, NOWEL, www.nowel.org). The objective of the network is to make area-wide care with the best available diagnostics and therapy accessible to lung cancer patients in Northern Germany.

At NOWEL, the region’s leading experts in the fields of oncology, pulmonology and pathology have joined forces in interdisciplinary and intersectoral cooperation to offer patients evidence-based, personalized cancer therapy of the highest scientific level. In doing so, NOWEL’s primary goal is to provide patients with close-to-home and timely diagnosis and treatment of their cancer. A main focus of NOWEL’s activities centers on health services research. With a comprehensive, quality-assured benefit analysis, NOWEL aims to actively contribute to improved diagnostic and therapeutic care concepts.

Company News: Lead Pharma Achieves First Milestone for Development of Autoimmune Diseases Treatments in Research Collaboration with Sanofi

Company receives undisclosed milestone payment

Lead Pharma, a pharmaceutical company developing innovative medicines for the treatment of autoimmune diseases and cancer, today announced that it has achieved the first milestone under its research collaboration with Sanofi, triggering an undisclosed milestone payment. The collaboration aims to develop small molecules directed against the nuclear hormone receptor ROR gamma (t) for the treatment of a broad range of autoimmune disorders, including common diseases such as rheumatoid arthritis and inflammatory bowel disease.

In February 2015, Lead Pharma and Sanofi announced a research collaboration and licensing agreement to discover, develop and commercialize small molecule therapies directed against ROR gamma (t), a key regulator of immune cells called T-helper 17 (Th17) cells. The current milestone payment follows an initial upfront cash payment at the start of the collaboration. Lead Pharma is eligible to receive further milestone payments and entitled to receive royalty payments on global sales from any resulting products. Financial details were not disclosed.

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