News

Food for Thought: Weekly Wrap-Up

Frankfurter Allgemeine Sonntagszeitung (FAS) this week in a special section (not online yet) deals with prion diseases such as Kuru, Creutzfeldt-Jakob disease, BSE and scrapie and the history of the discovery that some CNS disorders are caused not by pathogens, such as bacteria or viruses, but by infectious proteins. In one of the articles, Volker Stollorz deals with the implication of the discovery. It led to the notion that CNS diseases can be caused by misfolding of proteins, and meanwhile  about 2 dozen neurological disorders are classified as “proteopathies”, among them Alzheimer’s disease and Parkinson’s disease. Stollorz features research that points to the possibility that proteopathies spread through the body by some sort of domino effect. In this case, it cannot be ruled out that they are contagious – which would have enormous consequences for medicine. To rule out the possibility that modern medicine contributes to the spread of neurodegenerative diseases, some researchers already call for sterilizing medical instruments with procedures that also deactivate proteins.

Ralph Diemann in Süddeutsche Zeitung this week introduces photovoltaic company Konarka, which is using the site and machinery of Polaroid company to manufacture sheets producing electric current. Using the old Polaroid instant film technology, the company is printing conductive molecules on extremely thin, light and flexible films that can be applied to common goods – sunshades, car bodies, window panes or even clothes. First products – daypacks and bags producing current to charge mobile phones, already have reached the market. Other companies – BASF, Thyssen-Krupp and Bischoff Glastechnik – will follow suit, Diemann writes. Disadvantages at present are a very low efficiency, a durability of a few years only and a high price.

The Economist this week reports on experiments of various research groups, which have turned mind-reading into reality. The results are still crude, but already, recording brain activity has proven to be an inroad into this area.

Belle Dumé in The New Scientist makes the case for green tea and red laser to treat Alzheimer’s disease. While epigallocatechin gallate (EGCG), an ingredient of green tea can reduce beta amyloid plaques in the brain, red laser light which penetrates tissue and even bone can facilitate uptake of EGCG by the brain and by brain cells. The results come from animal experiments.

Last not least, Robert McMillan in Wired reports about the symbiotic relationship between IT and manure. IT company Hewlett-Packard (HP) seriously is thinking about using cow dung to power future data centers. These centers produce a lot of heat which can be used to heat cow dung for the production of methane, which in turn can power the data center.

Food for Thought: Why Do Private Companies Need IR, Too?

With an increasing number of emerging private equity trading platforms worldwide, it has become obvious that professional investor relations is not just for publicly listed companies. Even though transparency requirements for private companies are still much lower than those for listed companies, there are challenges ahead. While previously targeting a relatively small group of specialized private equity investors, private companies are now facing a very heterogenous audience of private (and, often times, anonymous) investors with very little knowledge about specific industy sectors and business models. Germany´s latest private equity market place, fianc, was launched earlier this week and follows the route of established players in the U.S. like SecondMarket and SharesPost.

It remains to be seen whether the new private equity trading platforms will eventually trigger more stricter regulatory and communication requirements – which, in turn, could mean that being a private company loses its charm. On the other hand, it is an excellent opportunity for private companies to broaden their shareholder base and attract additional capital. According to IR Magazine´s newsletter Inside Investor Relations, some analysts have started to focus entirely on this new market segment. That said, it is obvious that private companies need to re-think and adapt their communication strategies and resources if they want to position themselves successfully on the new trading platforms. Feel free to contact us if you need advice on trading your company´s shares on the private market.

Company News: Curetis AG Attracts Forbion and Roche As New Investors

– Series A financing round expanded to €34.1 million –

Curetis AG, an innovative molecular diagnostics company focusing on the development and commercialization of in-vitro diagnostic products for infectious diseases, today announced the expansion of its Series A financing round by € 9.6 million. The additional funds increase the round to a total of € 34.1 million and the total capital raised to date to € 36.6 million. The financing was led by Forbion Capital Partners together with Roche Venture Fund. CD-Venture and Curetis ́ management also participated in the round. Holger Reithinger, Partner at Forbion Capital Partners, has joined Curetis’ Board of Directors. Roche will get an observer seat on the Board of Directors.

Since its inception in 2007, Curetis AG has developed the versatile Unyvero™ instrument platform which handles disease-specific disposable cartridges for the analysis of various marker panels, covering both pathogens and antibiotic resistance genes. The Unyvero™ platform combines a unique, fully automated sample preparation working with a comprehensive range of native clinical sample types, with isolation, amplification and highly multiplexed detection of DNA. The simplified, automated and uniform work flow enables testing at the point of need, eliminates operator-induced variations and ensures high-quality results in a short time frame. The first application, a solution for comprehensive pneumonia testing, has successfully completed extensive pre-clinical testing, is about to enter into pivotal clinical trials towards regulatory clearance and is scheduled to enter the European market as a CE-marked device in 2012.

Food for Thought: Europe Will have to Buy Stem Cell Therapies in the US, Asia

The European Court of Justice today ruled that biological procedures cannot be patented if they are based on the prior destruction of human embryos, with “human embryo” defined in the broadest possible sense.

Background of the ruling is a patent filed by German stem cell researcher Oliver Bruestle in 1997. The patent covers isolated and purified neural precursor cells produced from human embryonic stem cells and used for the treatment of neurological diseases. The cells are already being used clinically for the treatment of patients suffering from Parkinson`s disease.

Greenpeace filed an opposition to the patent and after the Federal Patent Court, Germany, ruled that the patent was invalid in so far as it covers processes for obtaining precursor cells from human embryonic stem cells, Bruestle appealed to the Federal Court of Justice, Germany, which referred the case to the European Court of Justice, saying the concept of ‘human embryo’ was not defined in EU Directive 98/44/EC on the legal protection of biotechnological inventions. The question was whether the exclusion from patentability of the human embryo covers all stages of life from fertilization of the egg or whether other conditions must be met, for example that a certain stage of development is reached.

Today, the European Court of Justice stated that its decision was not about ethical or moral questions, but solely on the legal interpretation of the EU Directive, adding that the Directive defines “human embryo” in the widest possible sense, i.e. every human egg able to divide must be classified as a “human embryo”.  This even comprises enucleated eggs, into which the cell nucleus of a human body cell has been transplanted, as well as non-fertilized human eggs, in which cell division and further development have been stimulated without fertilization, e.g. by parthenogenesis. Taking the definition even further, it adds that all inventions that are based on the prior destruction of human embryos or their prior use as base material are excluded from patentability.

Greenpeace hailed the decision as a “landmark case”, stating the ruling was protecting humans from being commercially exploited. The press release was illustrated by the picture of a baby carrying a “patent clip” in its earlobes.

Oliver Bruestle, who was placed under police protection together with his family when the campaign against his patent application was started, commented that fundamental research on human embryonic stem cells can still take place in Europe – however, it means that “others will pick the fruits in the U.S. and in Asia.”

The ruling is the result of the EU’s Directive, which was adopted in 1998 after a decade of debates and compromises between the EU member states, the EU parliament and the EU Commission.

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