News
Innovation Radar: Living Pictures, Living Books
Everyone is talking about Web 2.0 – but only slowly the benefits of it are being integrated into consumer products. Here we introduce two novel examples for technologies greatly improving everyday products by adding features only possible thanks to the web.
The first product is Lytro, a camera capturing pictures without the need of focusing. The camera does not even look like a camera any more; it is just an angular aluminum tube surrounding the lens, with the aperture at one end and a display screen at the other – no viewer, no control buttons, only a power button, a shutter button and a zoom slider.
Just point and shoot, and focusing is done once the picture has been uploaded to the web. Simply push the mouse over the area of interest, click, and the focus is there. The pictures are HD quality, and users can switch between 2D and 3D views.
Technically, Lytro captures the entire light field of the scene when the shutter button is pressed, i.e. a sensor records not only color and intensity of the light rays, but also the vector direction – an information that is completely lost with conventional cameras. This information is later used to enable the selection of different batches of light, i.e. bringing different parts of the picture into focus.
The second product is Libroid, an ebook format designed to present books electronically not just by bringing letters to a screen, but by adding extra information such as films, photos, maps, links in a way that readers are not distracted if they choose to focus on the text.
The application designed for iPads is simple. Hold your iPad in portrait format and you can read the text without distraction by additional elements. If you switch to landscape format, two columns appear on the left and right side of the text. As an example, one column may display photos, while the other refers to further reading, etc. The columns scroll with the text so that always only matching information is displayed.
This is much more than just adding an interview with the author or some photos to an ebook. It allows for entirely new writing: a thriller author might provide the same scene from the perspective of different characters so that readers can switch easily between their heroes, a cookbook author may add videos or provide features to simply adapt recipe quantities to the number of eaters or recipe variations; non-fiction authors may provide sources, their research material and much more.
Both products already are on the market. Lytro sell its cameras from $399 in the US, while Libroid is available in Apple’s iTunes store (iPad only) for €7,99. Juergen Neffe, inventor of Libroid, still appreciates investors as German publishing houses keep being very conservative and are still not embracing the ebook market wholeheartedly.
Food for Thought: Weekly Wrap-Up
Thomas Jüngling in Die Welt introduces auxetic materials which have the unique property of becoming broader when stretched and more tight when crushed. The effect is not depending on the material used, but on the inner structure, so that auxetic materials can be designed from metals as well as plastics. Applications span from improved bulletproof vests to seals to better sofa cushions. In medicine, auxetic materials may be used as dressing, filters, e. g. for artificial lungs, or for the delivery of drugs from plasters.
Jürgen Rees in Wirtschaftswoche introduces a technology developed by car manufacturer Volkswagen which lets an electrically powered delivery van drive autonomously and by acclamation of its driver from outside. The car is designed for courier services.
The Economist this week takes a look at personal manufacturing as the potential “next big thing”. Could be, at least in areas of the world where industrial infrastructure is poor and capital rare, the paper says. Prices for 3D printers came down from more than $100,000 to $2,500; kits may amount to $500, thanks to start-ups in the field. Add costs for the thermoplastics ($1 a pound), free software and even freely available blueprints, and personal manufacturing seems to be at the same stage as the personal computer world was when Apple introduced the Apple II.
Jörg Albrecht and Volker Stollorz in Frankfurter Allgemeine Sonntagszeitung (FAS) report on a simple method to combine the deadly, but barely contagious bird flu virus with the highly infectious, but rarely lethal swine flu variant to a deadly and highly contagious novel flu virus. The new virus with an alleged mortality rate of 70% has been designed in the Netherlands and was reported by Science. Albrecht and Stollorz mention various other combination experiments to create deadly and highly contagious viruses, raising the question of whether the data should be published or not.
Valentin Frimmer in Frankfurter Allgemeine Zeitung (FAZ) reveals the mechanism of endoreduplication common in plants to multiply chromosomes without subsequent cell division. Endoreduplication allows for faster synthesis of enzymes and cell components and is economically and commercially very important as it contributes to about half of the global biomass growth.
In Neue Zürcher Zeitung (NZZ) Nicola von Lutterotti summarizes the biological and medical importance of nitric oxide, an important signaling molecule of the body. She explains successes and failures in developing nitric oxide-based drugs for the treatment of pain, high cholesterol levels, hypertension, and others.
Ärzte Zeitung reports latests insights into the EHEC epidemic which in Germany this summer caused 3,842 infections, including 855 cases of hemolytic-uraemic syndrome and 53 deaths. Ultimately the bacteria were discovered in a 15 metric ton charge of fenugreek seeds imported from Egypt; however, it was unclear why only the 75 kg of this lot delivered to an organic farm in Northern Germany and a few kilograms bought by a French farm led to outbreaks of the disease. Ärzte Zeitung writes that Martin Exner, director of the Institute for Hygiene at the University Clinic Bonn, Germany, believes that the bacteria were in a viable but non-culturable (VBNC) state in the charge. Already it has been shown that the EHEC strain causing the outbreak can adopt the VBNC state. It is also known that under certain circumstances infectious bacteria in VBNC state can be activated, e.g. by transit of the intestine. At least at one of the farms, workers regularly ate sprouts cultivated on the site and five of the workers were identified as eliminators. Exner speculates that a well used on the farm as a water source might have spread the bacteria as the toilets are located at the well house. As a result, Exner calls for improving hygiene standards in sprout-cultivating factories similar to clinics.
Company News: Micromet Initiates Global Phase 2 Trial of Blinatumomab in Adult Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia
Micromet, Inc. (NASDAQ: MITI) today announced that it has initiated a phase 2 trial of its lead product candidate blinatumomab (MT103) in adult patients with relapsed or refractory (r/r) B-precursor acute lymphoblastic leukemia (ALL). Blinatumomab is the first of a new class of agents called BiTE® antibodies, designed to harness the body’s T cells to kill cancer cells.
This phase 2, single-arm study will evaluate the efficacy and safety of blinatumomab in approximately 65 patients with relapsed/refractory Philadelphia-negative B-precursor ALL. Patients will receive blinatumomab daily for 28 days followed by two weeks off blinatumomab over a six week treatment cycle. Patients who achieve a complete remission (CR) or complete response without full recovery of platelets (CRh*) within two cycles of treatment will receive up to three additional cycles of consolidation treatment. The primary endpoint of the study is CR/CRh*. Secondary endpoints include duration of response and overall survival. The study will be conducted at approximately 40 leading cancer centers in the U.S. and EU. The Company currently expects to complete enrollment in this trial by year end 2012.
Additional information regarding this Phase 2 study is available at the U.S. government’s clinical trials database at http://www.clinicaltrials.gov.
Blinatumomab Clinical Experience in Adult R/R ALL
Interim results from a Phase 2 trial presented at the 2011 Meeting of the European Hematology Association show that blinatumomab produced a high CR rate in adult patients with ALL who had relapsed following treatment with standard therapy. 75% of patients (9 of 12) achieved a CR or CRh* following treatment with blinatumomab1. All nine responding patients achieved a complete molecular response, or had no evidence of leukemic cells in their bone marrow, a key prognostic factor for patient survival. Notably, four patients with genetic abnormalities typically associated with poorer outcomes all achieved a CR or CRh*. The most common clinical adverse events were fever, peripheral edema and fatigue. Treatment of two of the twelve patients was interrupted due to fully reversible and manageable central nervous system (CNS) events.