Tag: clinical trial
Mabylon AG Initiates Phase I Clinical Trial of Lead Compound MY006 for the Treatment of Peanut Allergy
— First study participant dosed in U.S. trial with healthy volunteers and patients with peanut allergy
— Novel, human-derived, half-life extended tri-specific monoclonal antibody to prevent allergic reactions
Mabylon AG, a leader in the high-throughput discovery, engineering, and development of human-derived antibodies for the treatment of allergies, neurodegenerative diseases, and inflammation, today announced that the first healthy volunteer has been dosed in the first-in-human clinical trial evaluating MY006, a novel tri-specific monoclonal antibody for the prophylactic treatment of peanut allergy. MY006 is based on patient-derived antibodies and designed to provide a new approach for preventing allergic reactions in individuals with peanut allergy.
tiakis Biotech Successfully Completes Data Package to Advance Tiprelestat into Phase II clinical trial in PAH
— 6-month GLP-tox study reinforces favorable safety profile of Tiprelestat
— Phase II Study in Pulmonary Arterial Hypertension (PAH) to be initiated by Stanford University in mid-2026
tiakis Biotech AG (“tiakis”), a clinical-stage biopharmaceutical company developing novel therapeutics for life-threatening pulmonary and cardiovascular diseases, today announced that the Company has successfully finalized a comprehensive data package to advance Tiprelestat into a Phase II clinical trial in Pulmonary Arterial Hypertension (PAH) by completing a preclinical GLP-tox study.
Thermosome Reports Encouraging Clinical Data of THE001 in Advanced Soft Tissue Sarcomas
— Heat-triggered release mechanism unequivocally confirmed
— Favorable safety profile with good tolerability
— Signs of encouraging clinical activity in heavily pre-treated patients including meaningful progression-free survival (PFS)
— One participant with previously unresectable disease in DL2 underwent surgery, indicating no vital tumor cells in the target lesion
Munich, Germany – June 24, 2025 – Thermosome GmbH, a clinical-stage drug development company focused on targeted tumor therapies, today announced new, encouraging data from its ongoing Phase I clinical trial evaluating its lead compound THE001 (DPPG2-TSL-DOX) in combination with regional hyperthermia (RHT) for the treatment of soft tissue sarcomas (STS). Read more…
Ebenbuild Contributes Cutting-Edge Digital Lung Simulations to Pulmonary Fibrosis Drug Development
— First-ever use of Ebenbuild’s Twinhale technology in idiopathic pulmonary fibrosis lung models
— Trial results published in Nature Communications
Ebenbuild, a company developing personalized, AI-enabled digital twins of lungs to support clinical decisions and digital clinical trials, today announced its contribution to a pioneering study published today in Nature Communications. The article titled Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment(DOI:10.1038/s41467-025-58568-x) highlights the potential of inhaled therapeutics for treating idiopathic pulmonary fibrosis (IPF), a devastating lung disease with limited treatment options. Read more…