Tag: The New York Times

Food for Thought: Weekly Wrap-Up

First signs of future onset of Alzheimer’s disease (AD) can be found already at the age of 14, reports Volker Stollorz in Frankfurter Allgemeine Sonntagszeitung (FAS). Introducing findings by Heiko Braak and Kelly del Tredici from Ulm University, he also points out that AD seems to originate in the Nucleus coeruleus region of the brain stem from which the typical AD clots slowly spread alongside nerve tracts. Stollorz features plans to include members of families with hereditary forms of AD in future clinical trials to test preventive drugs and treatments. Researchers in Germany currently are planning to launch a website and to found a network modeled according to the US “Dominant Inherited Alzheimer Network” (DIAN). Stollorz and his colleague Thomas Liesen also are co-authors of a TV documentary which can be found here for four weeks from July 19, 2011.

Jutta Hoffritz in Die Zeit reports on novel anticoagulants, e.g. Pradaxa by Boehringer Ingelheim, which is already marketed in the US, and similar drugs developed by Bayer Schering, Pfizer and Daiichi Sankyo. The drugs are developed to replace marcumar which carries the risk of severe side effects and is difficult to dose. However, while the new drugs show better efficacy and promise better compliance, Hoffritz cites German medical doctors expressing skepticism because of unknown long term risks and the anticipated high pricing of the drug. Ulrich Schwabe, editor of Arzneiverordnungsreport, a publication known to be very critical about the pharma industry, is quoted with the calculation that treating all eligible patients in Germany with Pradaxa would amount EUR 4.9 billion per year. The calculation is based on the price of the current daily dosis as the drug is already marketed in Germany for the prevention of thrombosis prior to knee and hip replacement surgery.

Christian Heinrich also in Die Zeit features a trend among pharma companies to search for potential applications of their already approved drugs. As an example, he introduces the “Common Mechanism Research” department of Bayer Schering AG, which is systematically studying unusual effects of Bayer compounds to find clues for novel therapeutic applications. Well-known examples of dual use compounds are sildenafil, which was originally developed to treat circulatory disturbance of the heart (now a common drug to treat erectile dysfunction), and aspirin, which was known as a pain killer and only later developed as anti-coagulant.

Christina Hucklenbroich in Frankfurter Allgemeine Zeitung (FAZ) reports on the suspicion that recently observed deaths of cattle in Germany may be caused by Clostridium botulinum bacteria. However, she points out the the jury is still out on whether there is a novel zoonosis called chronic botulism as presence of the toxin in minute amounts in the gut of affected animals is difficult to confirm. In addition, the source of the bacteria detected in some animals has not yet been identified.

Also in FAZ, Hildegard Kaulen reports on novel findings how smoking cigarettes suppresses appetite. Researchers from Yale University, she writes, found a hitherto neglected nicotine receptor in the brain, which influences the neuronal circuit involved in appetite regulation. Once nicotine binds to the receptor, the nerve cells start releasing the neurotransmitter POMC which in turn influences nerve cells regulating satiety feelings.

Nicholas Wade in The New York Times reports on efforts by scientists from Harvard Medical School to introduce hundreds of changes in the genome of E. coli bacteria simultaneously, an effort dubbed by a colleague as as “macho molecular biotechnology”. The alteration of 314 sites is just an intermediate step by George M. Church and Farren J. Isaacs to establish a method by which certain stretches of DNA could be changed just the way a word processor searches and replaces certain words in an entire document in one step. The researchers removed a particular stop codon (T-A-G, or “amber”) and replaced it by another (which works just as well). Now they are planning to also remove the gene recognizing the deleted stop codon and subsequently to reintroduce amber and reassign it a new function, e.g. to incorporate a novel amino acid into the bacterium’s proteins.

The Economist announces the world’s first  “World Cell Race” taking place in August. Cells sent in by various research institutions all over the world will compete against each other in the race to move towards a chemoattractant. The scientists thereby hope to identify genes involved in cell mobility which are known to be important drivers in cancer metastasis as well as wound healing and immune responses.

New Scientist recently featured a series of articles dealing with bacteria (“bugs that break all rules”): Caroline Williams introduces multicellular behavior of socializing bacteria, features bugs that hunt in packs, bacteria large enough to be visible with the naked eye and bacteria with backbones and cell compartments.

And finally, Cinthia Briseno in Der Spiegel reports on studies proving that the internet is changing the way we memorize and learn. The ability to rely on the internet seems to encourage people to make less mental notes of facts they are sure to find in the web with a few keystrokes.

Food for Thought: Weekly Wrap-Up

This week, Frankfurter Allgemeine Zeitung (FAZ) deals with potential origins of the enterohemorrhagic E. coli (EHEC) epidemic in Germany. Christina Hucklenbroich details the consequences of feeding cattle mixed provender, a forage that changes the environment of the intestinal tract so that it becomes an ideal habitat for bacteria like E. coli. In a separate article the same author deals with an EHEC outbreak in 1997 in the US which affected mostly women – similar to the current epidemic in Germany. Back then, the source had been alfalfa sprouts used in salads. While the ultimate source had never been found, scientists suspected that already the seeds had been contaminated. Richard Friebe, also in FAZ, deals with slurry from pigs, cattle, and fowl that is know to contain all sorts of bacteria and viruses. It is used either directly as fertilizer (though not on vegetables and salad plants) or may contaminate adjacent fields through spillover, spray or via irrigation using water contaminated with slurry.

Susanne Kutter in Wirtschaftswoche introduces Holger Zinke, co-founder and CEO of BRAIN AG, a biotech company specialized on “white” biotechnology, using the skills of microbes to re-design industrial processes or to come up with entirely new ones. Thereby, pharma and chemical industry can save energy, money, and expenses for raw materials. The article is part of a series on pioneers of the “greentech-era”, trying to change the industry to make it more energy-efficient and sustainable.

In Forbes, Matthew Herper analyses why scientists in Germany and China used small desktop sequencers by Ion Torrent rather than big machines by Illumina, Life or 454 Life Sciences to decipher the sequence of the EHEC strain rampaging through Germany. Herper claims it is speed and cost. However, the choice was also influenced by the fact that the sequence of the new strain matched strains with sequences available in public databases relatively closely so that puzzling together the short sequence data generated by the machine was easy.

In reporting on this year’s annual conference of the American Society of Clinical Oncology (ASCO), Andrew Pollack in The New York Times (NYT) introduces two drugs for the treatment of melanoma: vemurafenib (developed by Genentech, part of Roche Group), which attacks a specific mutation accelerating tumor growth and Yervoi ipilimumab (developed by Bristol-Myers Squibb), which unleashes the body’s immune system to fight the cancer. Yervoi was approved by FDA in March this year. Pollack also features latest clinical results for Aromasin exemestane, a drug marketed for preventing recurrences of breast cancer.

Gina Kolata, also in NYT, deals with the phenomenon of “linguistic toxicity”, i.e. drug labels listing more and more side effects, even contradictory ones such as that a medication can cause diarrhea or constipation. As of today, drug labels in the US list an average of 94 side effects (the top numbers already are exceeding 500), despite efforts of FDA to make drug makers avoid listing of side effects that are infrequent and minor, commonly observed in the absence of drug therapy or not plausibly related to drug therapy. Main reason is pharma companies trying to protect themselves against lawsuits.

Last not least, New Scientist features the latest advice for those of you on diet: psychologist found that if you succeed convincing yourself that everything you eat bears enormous amounts of calories, your ghrelin hormone level will drop much lower after eating so that you feel being full faster.

Food for Thought: Weekly Wrap-Up

Joachim Müller-Jung in Frankfurter Allgemeine Zeitung (FAZ) reports on the rapid spread of infections with enterohemorrhagic Escherichia coli (EHEC) in Germany. In about 20-25% of cases, the disease leads to the life-threatening hemolytic uremic syndrome (HUS) associated with kidney failure. Jung reports about promising treatment strategies using Soliris eculizumab. The monoclonal antibody by Alexion Pharmaceuticals has been approved in the US and the EU in 2007 for the treatment of paroxysmal nocturnal hemoglobinuria.

Also in FAZ, Nicola von Lutterotti features results from molecular psychiatry studies in children brought up in orphanages and adults suffering from trauma. Results demonstrate that there is a strong association between length of stay in an orphanage and factors like learning ability as well as length of telomers. Adults suffering severe trauma during childhood also have significantly shorter telomers.

In Focus, Monika Preuk reports on instant dental implants for diabetics, osteoporosis patients and smokers. These patients often cannot undergo conventional implantation procedures that need careful planning and complex steps of building bone material, placement of titanium posts and periods of long healing times. The new method involves skewed planting of very long implants into the healthy parts of the jawbones. The method stabilizes the jawbone so that implants can be planted within a day.

Matthew Herper in Forbes introduces the 25 most innovative countries in biology and medicine based on data provided by SciVal analytics, an Elsevier division. The complex analysis is based on publications output, number of citations, etc. Still the US dominates the fields, and papers by US scientists are more likely to be cited by other researchers than those in any country – except the Netherlands and Switzerland.

Andrew Pollack in the New York Times introduces Sherwood L. Gorbach, a researcher who helped to develop Dificid, a novel antibiotic against severe diarrheas. The drug by Optimer Pharmaceuticals has just been approved by FDA for the treatment of Clostridium difficile-associated diarrhea.

The Economist features new attempts to vaccinate people against drug abuse. The challenging task is to develop an effective vaccine against  really small and therefore very flexible molecules. A new trick applied for the design of a metamphetamine vaccine uses computer models to design haptens mimicking various metamphetamine-shapes and using these haptens to generate antibodies. Already it has been possible to generate efficacious metamphetamine-antibodies in mice with this method.

And finally, Die Zeit this week deals with the question whether mosquitos get drunk upon sucking blood from drunk people. The answer to the question is that after the blood meal, the mosquitos have about half the blood alcohol concentration of their victim. However, it is unclear whether they show behavioral deficits thereafter. 😉

Food for Thought: Weekly Wrap-Up

According to a study by researchers from the Center for Regenerative Therapies Dresden (CRTD, Dresden, Germany), it is possible to increase the brain’s pool of brain stem cells by overexpressing cdk4 and cyclinD1 via the introduction of programmed viral vectors. Subsequently, the increased stem cell pool leads to the increased production of neuronal cells, reports Die Welt. The study published in the Journal of Experimental Medicine was conducted in the brains of adult mice and may allow researchers to better understand the function of neuronal stem cells and to develop new therapies to combat neurodegenerative diseases.

Brain cell formation is also boosted by certain antidepressant drugs, reports Jessica Hamzelou in New Scientist. The study conducted at King’s College, London found that antidepressants such as sertraline work by acting on glucocorticoide receptors. However, they activate the receptor in a different way than glucocorticoide hormones.

Hayley Crawford in the New Scientist introduces the world’s first  computerized map of the human brain. This novel Human Brain Atlas developed by the Allen Institute for Brain Research in Seattle (Wash.) is an interactive tool scientists can use to search for data, e.g. all known locations in the brain where targets of a certain drug are expressed.

In Forbes, Parmy Olson reports on Seedcamp, a concept developed in 2007 by Index Ventures partners Saul Klein and Reshma Sohoni. Seedcamps are conferences in which start-ups present their business ideas and have the opportunity to sell a 8-10% equity stake in return for 50,000 Euros and a year-long support program. The conferences are held throughout Europe, but also in India, Singapore and South Africa. The program at present support 38 start-ups and is now expanding to the US.

The Economist reports on Asthmapolis, a US-based company, and its Spiroscout inhaler that comes with a built-in Global Positioning System locator and a wireless link to the internet. Whenever someone uses the inhaler, it broadcasts the location and time to a central computer. Asthmapolis plots and analyses the data, and sends weekly reports to participating patients and their doctors summarizing the observations and making recommendations.  The device allows to identify threats patients are unaware of and helps doctors identify those patients whose asthma is not under proper control.

Roni Caryn Rabin in The New York Times reports on a recent study in more than 800 elderly people. Researchers observed  that older people suffering from mild memory and cognition problems seem to be less likely to develop full-blown Alzheimer’s disease if they receive proper treatment for conditions such as high blood pressure, diabetes and cholesterol.

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