Tag: Curetis

Company News: Curetis to Launch Next-Generation Pneumonia Application at ECCMID 2015

Company Successfully Completes Clinical CE Performance Evaluation of Unyvero P55 Pneumonia Application

Clinical sensitivity across 40-marker panel averages 94% at 99.4% specificity

Curetis AG, a developer of next-level molecular diagnostic solutions, today announced the successful completion of the clinical and analytical CE performance evaluation of its next-generation Unyvero P55 Pneumonia Application. The upgraded cartridge will launch at the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID, April 25 – 28, 2015 in Copenhagen, Denmark) and is supported by more than 800 cartridge runs and over 400 patient samples.

Unyvero P55, which is replacing the current P50 cartridge, identified a total of 127 additional pathogens compared to microbiology culture. Discrepant results have been resolved by independent PCR and sequencing and validated 93 cases as true positives, e.g. cases where traditional microbiology culture missed the pathogen.

The Unyvero P55 Pneumonia Application demonstrates superiority over culture and key enhancements compared to the P50 cartridge, evidenced by pathogen and resistance expansions and improved sensitivity proven in the CE clinical performance study. Specific upgrades include:

  • Expansion to detect 21 pathogens, including new targets Mycoplasma pneumoniae, Citrobacter freundii, Enterobacter aerogenes and Klebsiella variicola
  • Addition of critical antibiotic resistance markers (now a total of 19), including genes coding for carbapenem (imp, ndm, vim, oxa-23, oxa-24, oxa-48, and oxa-58 markers) and oxacillin (mecC) resistance
  • Improvements to sensitivity for several analytes, i.e.
    • Greater than 90% for most pathogens on the P55 panel, including Pseudomonas aeruginosa
    • Greater than 92% for Staphylococcus aureus
    • Near 100% for Pneumocystis, E. coli and Moraxella catharralis.

Comprehensive data supporting the next-generation Pneumonia Application will be presented at ECCMID.

The European and international roll out (excluding North America) commences in April 2015. Pricing for the P55 Pneumonia Application remains unchanged from the P50 cartridge. In the U.S., the P55 is being used under the label LRT55 as a Lower Respiratory Tract (LRT) Application in a U.S. FDA clearance trial, which is expected to be completed in 2016.

Company News: Curetis Initiates Clinical CE Performance Evaluation of Unyvero P55 Pneumonia Application

Clinical study to test more than 400 patient samples

Follows successful completion of analytical CE Performance Evaluation in more than 400 cartridge runs

Expected results and product launch in spring 2015

Curetis AG, a developer of next-level molecular diagnostic solutions, today announced the start of the clinical CE performance evaluation of its next-generation Unyvero P55 Pneumonia Application. The new P55 Cartridge will replace the current P50 Pneumonia Application, which was launched in 2012. P55 will offer an even broader panel of pathogens and antibiotic resistance markers, reflecting global changes in the importance of microorganisms and certain critical resistance mechanisms responsible for pneumonia and other lower respiratory tract infections. Final study data and the P55 product will be presented at the upcoming 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) April, 25 – 28 2015 in Copenhagen, Denmark.

The clinical study will evaluate more than 400 already collected native samples from patients suffering from pneumonia. Primary endpoint of the study will be assay performance defined as clinical sensitivity and specificity as compared to microbiology culture, today’s diagnostics standard of care. Analytical sensitivity has already been established for all panel analytes in more than 400 P55 cartridge runs.

The P55 Cartridge comes with a panel of up to 21 pathogens and up to 19 antibiotic resistance markers. Additions are expected to include e.g. Mycoplasma pneumoniae, Citrobacter freundii, Enterobacter aerogenes, and Klebsiella variicola as well as clinically relevant resistance genes coding for carbapenem (imp, ndm, vim and several oxa-markers) and oxacillin (mecC) resistance. These enhancements reflect input from clinical and epidemiological findings, key opinion leaders and customers over the past two years and will support Curetis’ global product launch activities.

The new cartridge will replace the P50 Application on the European market. Pricing will remain unchanged, with an international roll-out expected to start in the second quarter of 2015. Under the label LRT55, the P55 Cartridge will also be used as a Lower Respiratory Tract (LRT) Application in the U.S. FDA clearance trial, which is expected to be completed in 2016.

Company News: Curetis Presents Product Updates at Intensive Care Conference

Multiple Unyvero product launches planned for 2015

Clinical trial aimed at US FDA clearance of Unyvero adapted to reflect most recent FDA guideline issued in Q3-2014

Curetis AG, a developer of next-level molecular diagnostic solutions, today announced the presentation of its product range at Germany’s biggest congress on intensive medicine and intensive care, Symposium Intensivmedizin + Intensivpflege, in Bremen from February 18-20, 2015. Curetis will be exhibiting the Unyvero Solution at booth #N27, hall 4 at Messe & Congress Centrum Bremen. Curetis is also providing an update on its pipeline of new products to be launched in 2015.

By the end of 2014, the installed base of Curetis´ Unyvero Solution has grown to more than 60 systems world-wide. Unyvero is a versatile hardware platform for the detection of a broad panel of bacteria, fungi and antibiotic resistances from a single sample in one run. At present, cartridges for pneumonia testing (Unyvero P50) and for implant & tissue infections (Unyvero i60 ITI) are available in Europe. The company is expecting the European launch of its enhanced and expanded Unyvero P55 Pneumonia application in the spring of 2015.

By mid 2015, Curetis also anticipates data from an updated i60 ITI application Cartridge. Moreover, the company is planning the launch of a comprehensive blood culture panel combining Gram-positive and Gram-negative pathogen markers as well as resistance markers by the end of 2015 in Europe.

The company also announced an update on its US trial of the Unyvero  LRT lower respiratory tract infection application. Curetis has adapted its FDA trial design to reflect the new guidelines issued by the FDA for multiplexed infectious diseases tests and will re-initiate prospective sample measurement once the enhanced and expanded P55 Pneumonia Cartridge is available as LRT-labeled test cartridges for the US FDA trial. Patient sample collection with the updated LRT application based on the P55 assay is expected to start mid-2015.

Curetis has decided to un-blind all data generated in its FDA trial to date and has engaged its network of US trial sites to continue collecting retrospective specimen. Data from the previous LRT study based on the P50 panel will be analyzed and published in a peer-reviewed format.

The new FDA guideline reduces the minimum number of required prospective patient samples to 1,500, limits requirements for prospective samples to only specificity endpoints, allows testing of retrospectively collected patient samples for sensitivity endpoints, and provides clarity on positive and negative control samples. Based on the adapted design and a start of patient sample collection with the new LRT55 application, which is anticipated by mid-2015, Curetis is expecting completion of patient enrolment in the first half of 2016, with subsequent filing with the FDA.


Company News: Curetis Closes EUR 14.5 Million Extension of Series B Financing

–      Curetis wins new investors QIAGEN and LSP-HEF, committing EUR 7 million

–      Curetis well financed into 2017

Curetis AG, a developer of next-level molecular diagnostic solutions, today announced it has closed a EUR 14.5 million extension of its Series B financing round, which was originally led by HBM Partners in April 2013. All existing investors – aeris Capital, BioMed Invest, CD Venture, Forbion Capital, HBM Partners, LSP – Life Sciences Partners, Roche Venture Fund, management, a trustee-pool of Curetis employees and private angel investors – participated in the extension financing, investing EUR 7.5 million on a pro rata basis. QIAGEN and LSP Health Economics Fund (LSP-HEF) are joining as new investors, committing a total of EUR 7 million. The financing brings the total amount of equity raised by Curetis AG to over EUR 63.5 million.

In addition, Rudy Dekeyser of LSP-HEF will join Curetis´ Supervisory Board, while Hans-Guenter Hohmann will step down after being a Board member for the past six years. Dr. Martin Potgeter, Vice President Business Development of QIAGEN, will take an observer seat on the board as second representative of a corporate investor alongside Simon Meier of Roche Venture Fund and Dr. Karsten Fischer of BioMed Invest.

The financing is supported by the achievement of key milestones, e.g. several CE/IVD-marked products, an ongoing FDA clearance trial and a growing commercial distribution network across Europe. The European market introduction of both the Unyvero P50 Pneumonia and i60 Implant and Tissue Infection applications, allowing a faster and better diagnosis of life-threatening infectious diseases, has shown increasing traction. In addition, the company is in talks with several parties on granting future U.S. commercialization rights and further expanding the commercialization into Asia and other global markets.

1 2 3 6