Tag: Wirtschaftswoche

Food for Thought: Weekly Wrap-Up

Andreas Menn in Wirtschaftswoche introduces the latest medical applications of smartphones for monitoring physical functions, ranging from the heartbeats of unborn children to blood sugar, blood pressure and pulse rates of elderly people to even pacers and other implants. According to Menn, the Mobile Health sector has a 19% market growth. In the US, patients are joining movements like The Quantified Self to collect health data for research purposes (and, as an example, to determine the ideal moment for wake-up). Contact lenses measure and report blood sugar levels, while tests strips or clothes with in-built wearable electronics control breathrate, wound swelling and urine for dangerous deviations. The field is still littered with startups, but big players like Siemens, Philips, sanofi aventis and Deutsche Telekom also have stepped in already.

Joachim Müller-Jung in Frankfurter Allgemeine Zeitung (FAZ) reports from the recent meeting of the Stem Cell Network North Rhine Westphalia. The debates focused on quality control of induced stem cells and the ability to derive motor neurons from such stem cells.

In The New York Times, Nicholas Wade reports on a recently discovered bundle of genes regulating the growth of heart muscles cells. The study published in Science will be of great interest for the development of novel therapeutics. It is known today that heart muscle cells are replaced in humans – however, the growth rate is too slow to replace the loss of many cells, e.g. in a heart attack. By modulating these genes, it might one day be possible to regenerate heart muscle in a targeted manner.

In Wired, Brandon Keim features a proposal by theoretical physicists that bacteria might transmit electromagnetic signals by using their DNA chromosomes as an antenna. The proposal is likely to trigger controversy as many biologists doubt that bacteria emit electric signals. French nobelist Luc Montagnier had already claimed in 2009 that bacteria do transmit radio signals in the 1 kHz range.

In the New Scientist, Ferris Jabr introduces a super twisty beam of laser light that is able to tell left-hand molecules from right-hand ones, with potential applications in drug development. Rowan Hooper reports on successful attempts to cure certain forms of blindness by introducing genes from algae into the eyes. The genes are encoding for channelrhodopsin-2 (ChR2), a photosensitive protein used by unicellular algae to orient towards light. The mice carrying a hereditary form of blindness were treated with subretinal injections of viruses carrying the algal gene and subsequently were able to use light beams for orientation in a maze. Trials in humans, the article states, might begin in two years. Finally, Andy Coghlan features findings that humans can be grouped by one of three gut ecosystems. These three “enterotypes” – dominated by three different species each – have been found all over the world and have a bias towards degradation of certain nutrients and production of certain vitamins.

And finally, for those of you who loved the Get a Mac ads by Apple (“I’m a Mac, I’m a PC”), please have a look at the ad campaign of Ion Torrent comparing its PGM sequencer to competitors such as MiSeq.

Food for Thought: Weekly Wrap-up

Die Welt this week reports on attempts by researchers from the University of Heidelberg to grow a human heart as a replacement organ. As a matrix, they plan to use the collagen structure of a pig’s heart depleted by all its cells. The structure will be incubated in a bioreactor with the cells of the patient who needs a new heart.

How damaged arteries or wounded skin may be regenerated by a new method, which will be available soon, is described by Wendy Zukermann in New Scientist. The trick is done by turning tropoelastin, a precursor of elastin found in skin and blood vessels, into a flexible fabric by electrospinning. The technology will now be further explored with support by Australian biotech company Elastagen.

Novel insights into how tetrahydrocannabinol, or THC,  exerts its mind-altering and pain-relieving effects revealed that THC binds to different molecular targets on cells to produce the to effects. As Andy Cochlan describes in New Scientist, the pain-relieving effect is caused by THC binding to glycine-receptors, increasing their activity. The typical “high” in contrast is caused by THC binding to the cannabinoid type-1 receptor (CB1). As a result, it may now be possible to create new pain killers.

In the same magazine, Mark Buchanan features a computer model of neural networks supporting the idea that the symptoms of Parkinson’s disease are caused by excessive uncontrolled synchronization of neurons. This makes it more difficult for the brain to end a task or begin a new one. In healthy brains, neurons fire synchronously only in a brief and controlled way.

Gina Kolata in the New York Times features two new, large gene association studies on Alzheimer’s disease that led to the discovery of five novel genes involved in the disease, making onset more likely and/or influencing disease progression. The studies, which are to appear today in Nature Genetics, confirm already existing hypotheses that the onset of AD is linked to inflammatory processes in the brain as well as to blood cholesterol levels.

The Economist introduces a powerful new battery suitable for cars that can be recharged completely in minutes. It is based on Nickel and charging rates are ten to 100 times higher than that of marketed battery. However, the development is still at a very early stage.

Much more advanced is a revolutionary car battery developed by German DBM Energy. The lithium polymer based battery enabled an electrically powered Audi A2 last autumn to drive 600 km from Munich to Berlin without recharging and has now been meticulously tested by the Germany’s Federal Institute for Materials Research and Testing (BAM). Jürgen Rees in Wirtschaftswoche reports that  BAM found the battery to be safe and confirmed the extraordinary cruising range. In the BAM tests, the car drove more than 450 kilometers on a single charge. Media reports had cast doubt about the features and performance of the battery after the test car was destroyed by a fire shortly after the record drive last year.

Food for Thought: Weekly Wrap-Up

Sebastian Matthes, Thomas Kuhn, Dieter Duerand and Susanne Kutter this week in Wirtschaftswoche introduce the winners of Innovationspreis 2011 (innovation award 2011). In the “Startup” category, the winner is Human Machine Intelligence, a Heidelberg-based IT company that developed the “Lingua” software able to understand and answer complete spoken sentences. “Big corporation” category winner is machine building company Freudenberg for its development of production processes that save 85% steel and do not produce waste. In the “medium-sized business” category, the winner is med tech firm Carl Zeiss Meditec which developed Intrabeam, a new cancer radiation therapy device that saves breast cancer patients week-long radiation therapy cycles and improves quality of life.

Also in Wirtschaftswoche, Andreas Menn features innovative printing technologies based on conductive ink and provides glimpses into the future of organic electronics for everyday products: flexible and printed electronic displays for ads and packages, loudspeakers from plastic foil, broadcasting metro tickets and pill containers that inform a cell phone software once a patient has withdrawn a pill. Among others, the article introduces German startup Printechnologics, based in Chemnitz, whose Aircode Touch technology can mark any type of paper with an invisible code that can be recognized and processed by smartphone touchscreens so that it can direct users to websites and/or authenticity certificates. Another German startup, Heliatek in Dresden, is developing printed solar cells that are to be sold by the meter in building supply stores.

Steven Salzberg in Forbes this week features a vitriolic comment of the decision of respected BioMedCentral (BMC), owned by Springer Science publishing house, to add a journal devoted to “Traditional Chinese Medicine”, or TCM,  to its portfolio of respected, peer-reviewed scientific journals. He introduces a “laughably bad study” and states, readers should bring “a high tolerance for quackery”, concluding: “BMC should be embarrassed to be publishing journals that promote anti-scientific theories and otherwise muddy the literature. By supporting these journals, they undermine the credibility of many excellent BMC journals. They should cut these journals loose.”

The Economist this week writes about “a serious gap in biologists’ understanding of the diversity of life”, featuring metagenomics research results that points to the existence of a new domain of life in the oceans, adding to the already known domains of archaea, bacteria, and eukaryotes. Another feature deals with back-scattering interferometry (BSI) that can be applied to studying membrane proteins unmodified and in situ using a laser in a simple, low-cost way. The technology may be used to study the interference of membrane receptors with drug candidates and to understand side effects and differences in the response of patients to already marketed drugs. Already, the inventors founded a startup, Molecular Sensing, in San Francisco, Calif.

In New Scientist this week, Helen Thomson reports that a brain electronic implant in a paralyzed women successfully passed the 1,000-day milestone. Wendy Zukerman describes that a new, non-invasive test might soon be available to diagnose the nerve damage associated with diabetes to predict the amputation risk of diabetes patients, and Peter Aldhouse writes about his first encounter with robots at Complete Genomics, a California-based startup that offers large-scale, complete human genome sequencing services as an end-to-end outsourced service to companies and research institutions.

Food for Thought: Weekly Wrap-Up

In Germany, science pages were dominated by Japan’s nuclear disaster. Apart from topics such as radioactivity as a threat to human health and the environment, Christiane Hucklenbroich in Frankfurter Allgemeine Zeitung (FAZ) deals with an upcoming new definition of autism. Instead of seeing autism as a defined disease category, physicians have come to the conclusion that one should rather use the term “autism spectrum”, comprising several aspects of autism. The medical community also has started focusing on co-morbidity aspects as well as autism-like symptoms in other psychiatric diseases.

Susanne Kutter in Wirtschaftswoche summarizes latest advances in stem cell medicine. Among others, she features a clinical trial conducted at the University of Rostock in which the heart muscle of patients suffering from an infarction is injected with adult stem cells to initiate regeneration of muscle. The trial includes more than 150 patients and will be finished end of 2012. A method already successful has been established in India, where more than 700 people with blindness caused by Vitamin A deficiency regained eyesight after injection of stem cells into the cornea.

Roni Caryn Rabin in The New York Times reports on a Lancet study that pooled data from 58 studies involving more than 220,000 people with a mean age of 58 to find out whether the idea that obese people with an apple shape (carrying the overweight predominantly in the belly) are more at risk for heart disease than overweight people with a pear shape. The answer is: they are not. Overweight matters, but shape does not.

Ferris Jabr in New Scientist introduces a small implantable device developed by researchers from the  Massachusetts Institute of Technology (MIT) that can track tumor growth in the body of cancer patients. The device contains magnetic nanoparticles covered with monoclonal antibodies able to bind cancer-related molecules, e.g. human chorionic gonadotrophin (hCG), a hormone released by testicular and ovarian cancers. The first generation had read-out by MRI scans that detect formation of clusters within the device due to binding of the molecules. However, the researchers now improved detection so that readout can now be done by a hand-held device. The principle can also be adapted to monitor other changes in the body, e.g. silent heart attacks.

For blood transfusion, medical doctors need to carefully choose the right blood group from 29 possible combinations of the AB0, Rhesus, the MNS and other systems. This challenge sometimes needs to complications and logistic problems. The Economist reports on a successful approach by researchers from the University of Montreal to disguise the antigenic proteins from red blood cells. The trick is done by first dressing the fatty surface membrane of the cells and then attaching another cover so that the immune system does not pay attention to the cells. The cover is fully permeable by oxygen and carbon dioxide.

David Whelan in Forbes calls for a psychological study of people investing in biotech stocks, in particular those writing rude comments on articles featuring the ups and downs of stocks. He claims the phenomenon is only seen with articles on biotech stocks.

And finally, David M. Ewalt in Forbes reports about errors in Craig Venter’s first synthetic life form in which Venter inserted DNA composed on a computer. The DNA included quotes from James Joyce and Richard Feynman, however Craig used the Joyce quote without written permission from Joyce’s estate and misquoted Feynman by obtaining the quote from the internet. Craig said he was now going back to the organism to correct the error.

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