News
Company News: Scil Technology Appoints Christian Nafe to Chief Executive Officer
Scil Technology GmbH, a biopharmaceutical company having its core expertise in protein drug development, formulation and analytics, today announced that Christian Nafe, currently Chief Financial Officer of the company, has been appointed to CEO. He succeeds Dr. Weishui Weiser, who retires after 5 years as Managing Director of Scil Technology. For further information, please click here.
Company News: biocrea Announces Novel Treatment Opportunities for CNS Diseases
– Company has filed US patent on novel, brain-penetrating PDE2 and PDE10 inhibitors –
CNS company biocrea today announced it has filed a patent application covering its brain-penetrating inhibitors of phosphodiesterases. These compounds constitute a new generation of promising drug candidates to address several CNS disorders that are currently lacking effective treatment options. biocrea has submitted a patent application to the U.S. Patent Office (USPTO) covering compounds and uses of its proprietary PDE2 and PDE10 inhibitors.
While the inhibitors of PDE10 show excellent potential for the treatment of schizophrenia, Huntington’s disease and Tourette’s syndrome, the PDE2 inhibitors cover a whole spectrum of new biological activities and treatment opportunities. Moreover, biocrea’s brain-penetrating PDE2 inhibitors show promise for the treatment of drug-induced movement disorders.
biocrea’s patent application also comprises dual inhibitors of PDE2 and PDE10 as the combination of both modes of action in one molecule results in synergistic biological effects.
So far, validating the benefit of brain PDE inhibitors in CNS diseases has been difficult because access to brain PDEs is limited by the so-called “blood brain barrier” (BBB). The team of biocrea has overcome these limitations and developed brain-penetrating, highly specific PDE inhibitors that constitute a new generation of promising drug candidates for the treatment of CNS disorders. The most advanced compound of biocrea’s novel family of PDE inhibitors, a brain-penetrating, selective PDE2 inhibitor, has been selected to enter pre-clinical development.
Food for Thought: Weekly Wrap-Up
Matthew Herper of Forbes this week takes up the issue whether a DNA sequencer can get FDA approval and quotes Jay Flatley, president and CEO of Illumina as saying the company is in talks with FDA to get regulatory clearance to use its technology for medical diagnostics. He also writes about the late Adriana Jenkins, who worked for Celgene and Third Rock Ventures, among others, and died of breast cancer earlier this month. Having been treated as one of the first patients with one of the first personalized drugs, Herceptin, which gave her a decade of life, she calls for a new law that would give drug companies extended monopolies for developing personalized medicines. Her own last article explaining her plea for supporting personalized medicine by a legislation similar to the Orphan Drug Act is featured in Forbes, too.
Also in Forbes, Robert Langreth explains why Novo Nordisk decided to abandon development of diabetes pills and to ramp up insulin production instead – a move highly successful so far.
Company News: Provecs Medical Signs Vaccine Collaboration with Bernhard Nocht Institute for Tropical Medicine
Hamburg-based immunotherapeutics company Provecs Medical this week announced the signing of a collaboration with the prestigious German Bernhard Nocht Institute for Tropical Medicine (BNI). The partners will design and evaluate novel vaccine candidates based on Provecs Medical’s technology platform. Indications are four undisclosed infectious diseases, three of them transmitted by insects.
Provecs Medical uses a proprietary adenoviral vector technology to achieve the targeted expression of multiple signaling molecules relevant for the immune system in the microenvironment of a disease site. Please click here for further information.